Evaluation of mannitol effect in patients with acute hepatic failure and acute-on-chronic liver failure using conventional MRI, diffusion tensor imaging and in-vivo proton MR spectroscopy

Table 8 Change in brain volume and cerebrospinal fluid (CSF) volume values (mean ± SD) in units of cubic centimeter from different white and gray matter regions in controls, patients with acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) before the intravenous infusion of mannitol (pre-mannitol study) and after receiving mannitol (post-mannitol study)

Volume	Study
	Control (n = 5)			ALF Patient (n = 5)			ACLF Patient (n = 5)
	Pre-mannitol	Post-mannitol	P	Pre-mannitol	Post-mannitol	P	Pre-mannitol	Post-mannitol	P
Brain volume	1303.47 ± 54.95	1308.88 ± 64.95	0.75	1130.76 ± 86.73	1162.39 ± 77.75	0.47	1096.85 ± 79.55	1076.90 ± 71.63	0.60
CSF volume	84.05 ± 4.88	85.10 ± 6.46	0.60	73.77 ± 19.72	73.27 ± 19.53	0.47	76.77 ± 18.68	83.84 ± 22.09	0.12