Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence

Table 1 Microsatellite alterations of un-diluted and diluted DNA in different esophageal tissues

Tissue DNA	Number studied	MSI			LOH
		Negative	At≥1 locus	At≥2 loci	Negative	At≥1 locus	At≥2 loci
Classification
SCC	23	12	5	6	17	3	3
ADC	18	11	4	31	15	2	12
Normal
Undilution	8	8	0	0	8	0	0
Dilution	8	3	2	33	4	2	24
Metaplasia
Undilution	8	7	1	0	7	1	0
Dilution	8	1	4	35	2	3	36
Dysplasia
Undilution	8	7	1	0	7	1	0
Dilution	8	1	3	47	2	2	48
Carcinoma
Undilution	8	6	2	0	6	2	0
Dilution	8	0	3	59	0	4	410

Normal: Normal esophageal squamous epithelium DNA; Metaplasia: Barrett esophageal columnar epithelium DNA; Dysplasia: Dysplastic esophageal epithelium DNA; Carcinoma: Esophageal adenocarcinoma DNA;

¹P = 0.758,

²P = 0.696,

³P = 0.026,

⁴P = 0.069,

⁵P = 0.009, ⁶P = 0.034,

⁷P = 0.009,

⁸P = 0.029,

⁹P = 0.004,

¹⁰P = 0.004 vs other groups.