Heparanase expression, degradation of basement membrane and low degree of infiltration by immunocytes correlate with invasion and progression of human gastric cancer

Figure 1 Expression and distribution of S100 protein and heparanase mRNA in gastric cancer tissues. Immunohistochemical staining of S100 protein (× 400) with a high density of tumor infiltrating dendritic cells positively stained for S100 protein in the early stage gastric cancer tissues (A) and a low density of such cells in the late stage gastric cancer tissues (B), heparanase mRNA expression by in situ hybridization (× 400) with a low heparanase mRNA expression level in the early stage gastric cancer tissues (C) and a high heparanase mRNA expression level in the late stage gastric cancer tissues (D) (Arrows: Positively expressed cells).