PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer

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Jun 28, 2008 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jun 28, 2008; 14(24): 3804-3811
Published online Jun 28, 2008. doi: 10.3748/wjg.14.3804

Table 2 PTEN protein expression in gastric cancer and paracancerous tissue samples and intensity distribution n (%)

Clinicopathological parameters	Cases	PTEN protein expression				P
Clinicopathological parameters	Cases	-	+	++	+++	P
Paracancerous	53	0 (0.0)	10 (18.9)	18 (34.0)	25 (47.2)	< 0.005
Gastric cancer	53	18 (34.0)	17 (32.1)	15 (28.3)	3 (5.7)
Differentiation extent						< 0.005
Moderate and high differentiation	26	4 (15.4)	6 (23.1)	10 (38.5)	6 (23.1)
Low differentiation	27	14 (51.9)	8 (29.6)	3 (11.1)	2 (7.4)

Citation: Guo CY, Xu XF, Wu JY, Liu SF. PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer. World J Gastroenterol 2008; 14(24): 3804-3811
URL: https://www.wjgnet.com/1007-9327/full/v14/i24/3804.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3804