Autoantibodies in primary sclerosing cholangitis

doi:10.3748/wjg.14.3781

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Jun 28, 2008 (publication date) through Jan 12, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2008; 14(24): 3781-3791
Published online Jun 28, 2008. doi: 10.3748/wjg.14.3781

Table 1 Autoantibodies detected in PSC patients

Antibody	Prevalence (%)	(Median)	No. of patients	(Median)	No. of articles
Anti-BEC	63	(63)	30	(30)	1[36]
pANCA	26-94	(68)	13-86	(30)	19 (Table 2)
AMA	0-9	(0)	15-73	(37)	10[44 61 78 89 102 112 137–140]
Anti-LKM	0	(0)	10-80	(37)	7[44 89 112 137 140–142]
Anti-SLA/LP	0	(0)	10-37	(25)	4[44 89 140 142]
ANA¹	8-77	(30)	13-73	(35)	13[44 61 78 89 99 101 102 111 112 137–140]
SMA¹	0-83	(17)	10-73	(36)	10[44 61 78 89 111 112 137–140]
ASCA	44	(44)	25	(25)	1[115]
Anti-cardiolipin	4-63	(27)	23-73	(41)	3[61 78 87]
Rheumatoid factor	15	(15)	71	(71)	1[78]
AECA	35	(35)	20	(20)	1[87]
Anti-TPO	16	(16)	73	(73)	1[78]
Anti-GBM	17	(17)	24	(24)	1[87]
Anti-sulfite oxidase	33	(33)	39	(39)	1[130]
Anti-GSTT1	5	(5)	58	(58)	1[133]

PSC: Primary sclerosing cholangitis; Anti-BEC: Antibodies against biliary epithelial cells (measured with flow cytometry); PANCA: Perinuclear antineutrophil cytoplasmic antibodies; ANA: Antinuclear antibodies; SMA: Smooth muscle antibodies; ASCA: Anti saccharomyces cerevisiae antibodies; AMA: Anti-mitochondrial antibodies; Anti-LKM: Liver-kidney microsomal antibodies; Anti-SLA/LP: Antibodies against soluble liver antigen/liver pancreas; AECA: Anti-endothelial cell antibodies; Anti-TPO: Antibodies against thyroid peroxidase; Anti-GBM: Antibodies against the glomerular basement membrane; Anti-GSTT1: Antibodies against glutathione S transferase theta 1.

¹In the largest cohort investigated, ANAs and/or SMAs were detected in 22% (24/111) of the PSC patients, but the frequency of each type was not given[143].

Citation: Hov JR, Boberg KM, Karlsen TH. Autoantibodies in primary sclerosing cholangitis. World J Gastroenterol 2008; 14(24): 3781-3791
URL: https://www.wjgnet.com/1007-9327/full/v14/i24/3781.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3781