Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests

Table 3 Multiple linear regression predicting peripheral blood T lymphocyte subpopulation (n = 216)

	CD3+ T lymphocyte			CD4+ T lymphocyte			CD8+ T lymphocyte			CD4+/CD8+ ratio
	β	SE	P	β	SE	P	β	SE	P	β	SE	P
Intercept	79.54	3.03	-	40.09	1.78	-	25.78	1.88	-	1.5	0.09	-
Serum HBV load (log, copies/mL)1	-3.65	0.43	< 0.0001	-1.38	0.25	< 0.0001	1.36	0.26	< 0.0001	-0.08	0.01	< 0.0001
HBeAg negative	0.05	1.98	0.98	0.61	1.16	0.6	0.5	1.22	0.69	-0.02	0.06	0.74
Age at HBV-infection(yr)2			0.06			0.63			0.19			0.02
8-20	-1.53	1.8		0.27	1.05		1.52	1.11		-0.03	0.05
> 20	-4.77	2.08		1.2	1.22		-1.28	1.28		0.15	0.06
Unknown	1.28	2.55		1.64	1.49		-0.77	1.58		0.13	0.08
Maternal HBV-infection status	2.17	1.74	0.21	0.31	1.02	0.77	-2.45	1.08	0.02	0.06	0.05	0.27

β: Coefficients from the model; SE: Standard error.

¹Continuous variable;

²control group, < 8 yr of age at HBV infection.