Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status

doi:10.3748/wjg.14.3662

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Jun 21, 2008; 14(23): 3662-3671
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3662

Table 3 Association between MTHFR genotypes and tumor methylation in relation to clinical-biological features of CLC patients (case-control comparison, n)

Genotype (%)	Controls	Cases	Methylated	OR (95% CI, P)^1,2	Unmethylated	OR (95% CI, P)^1,2
Total	81	151	44		107
CC	40 (49.4)	64 (42.4)	15 (34.1)	1	49 (45.8)	1
CT	31 (38.3)	80 (53)	28 (63.6)	2.5 (1.1-5.6, 0.02)	52 (48.6)	1.4 (0.7-2.6, 0.3)
CT or TT	41 (50.6)	87 (57.6)	29 (65.9)	2.1 (0.9-4.5, 0.07)	58 (54.2)	1.1 (0.7-2.1, 0.6)
Sex
Male	50	90	21		69
CC	28 (56)	33 (36.7)	5 (23.8)	1	28 (40.6)	1
CT	17 (34)	51 (56.7)	15 (71.4)	5.3 (1.6-18.2, 0.008)	36 (52.2)	1.9 (0.9-4.3, 0.09)
CT or TT	22 (44)	57 (63.3)	16 (76.2)	4.3 (1.3-14.3, 0.01)	41 (59.4)	1.7 (0.8-3.6, 0.1)
Female	31	61	23		38
CC	12 (38.7)	31 (50.8)	10 (43.5)	1	21 (55.3)	1
CT	14 (45.2)	29 (47.5)	13 (56.5)	1.1 (0.3-3.6, 0.9)	16 (42.1)	0.7 (0.2-1.9, 0.5)
CT or TT	19 (61.3)	30 (49.2)	13 (56.5)	0.9 (0.3-2.8, 0.8)	17 (44.7)	0.5 (0.2-1.4, 0.2)
Age
< 60	40	66	19		47
CC	18 (45)	31 (47)	6 (31.6)	1	25 (53.2)	1
CT	18 (45)	34 (51.5)	13 (68.4)	1.4 (0.4-5.1, 0.6)	21 (44.7)	0.8 (0.3-1.9, 0.6)
CT or TT	22 (55)	35 (53)	13 (68.4)	1.1 (0.3-3.8, 0.9)	22 (46.8)	0.7 (0.3-1.6, 0.3)
≥ 60	41	85	25		60
CC	22 (53.7)	33 (38.8)	9 (36)	1	24 (40)	1
CT	13 (31.7)	46 (54.1)	15 (60)	3.8 (1.2-12.0, 0.02)	31 (51.7)	2.6 (0.9-6.6, 0.09)
CT or TT	19 (46.3)	52 (61.2)	16 (64)	2.7 (0.9-8.2, 0.08)	36 (60)	1.9 (0.8-4.2, 0.1)
Site
Proximal		60	43		17
CC		22 (36.7)	15 (34.9)		7 (41.2)
CT		37 (61.7)	27 (62.8)	2.7 (1.2-6.2, 0.02)	10 (58.8)	1.4 (0.5-4.8, 0.4)
CT or TT		38 (63.3)	28 (65.1)	2.1 (1.03-4.99, 0.05)	10 (58.8)	1.2 (0.4-3.7, 0.7)
Distal		91	1		90
CC		42 (46.2)	0 (0)		42 (46.7)
CT		43 (47.3)	1 (100)	ND	42 (46.7)	1.3 (0.7-2.5, 0.4)
CT or TT		49 (53.8)	1 (100)	ND	48 (53.3)	0.9 (0.5-1.6, 0.7)

^1,2For odds ratio and 95% CI calculations, controls with CC genotype was used as reference category, odds ratio adjusted for age, sex and smoking status. ND: Not determined.

Citation: Mokarram P, Naghibalhossaini F, Firoozi MS, Hosseini SV, Izadpanah A, Salahi H, Malek-Hosseini SA, Talei A, Mojallal M. Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B₁₂ status. World J Gastroenterol 2008; 14(23): 3662-3671
URL: https://www.wjgnet.com/1007-9327/full/v14/i23/3662.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3662