Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice

Figure 6 Immunohistochemical atlas of Bcl-2 and Bax expression in four groups (× 200). Bax expression is shown in normal saline group (A), CTS-Pasp group (B), 5-Fu group (C) and CTS-Pasp-5Fu group (D). Bcl-2 expression is shown in normal saline group(E), CTS-Pasp group (F), 5-Fu group (G) and CTS-Pasp-5Fu group (H). The masculine express of Bax in was CTS-Pasp-5Fu group was more obvious than that in the 5-Fu group. CTS-Pasp-5Fu and 5-Fu could up-regulate Bax expression compared with NS. The masculine expression of Bcl-2 in the CTS-Pasp-5Fu group was obviously lower than that in the other three groups. Both CTS-Pasp-5Fu and 5-Fu could both down-regulate the Bcl-2 expression.