Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients

doi:10.3748/wjg.14.3490

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Jun 14, 2008 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Jun 14, 2008; 14(22): 3490-3496
Published online Jun 14, 2008. doi: 10.3748/wjg.14.3490

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Figure 2 Construction of replicons of clinical HBV isolates using pHY106. Full-length HBV genomes from PCR amplication can be digested with Sap I and inserted into Sap I-digested pHY106 to produce HBV replicon. HBV open reading frames (ORFs) for the pre-core (PC), core, preS1 (PS1), preS2 (2) surface (S), polymerase, and X genes are indicated by square frame. Promoter sequences for the preS (PS), surface (S) and core (C) genes are indicated by arrows.

Citation: Lu YP, Guo T, Wang BJ, Dong JH, Zhu JF, Liu Z, Lu MJ, Yang DL. Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients. World J Gastroenterol 2008; 14(22): 3490-3496
URL: https://www.wjgnet.com/1007-9327/full/v14/i22/3490.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3490