Relationship between T-lymphocyte cytokine levels and sero-response to hepatitis B vaccines

Table 1 Levels of cytokines secreted in vitro from PBMC of high, hypo and non-responder adults following stimulation with HBsAg

Cytokines/units	Stimulations	High-responders	Hypo-responders	Non-responders	P value	Multiple comparison2
IFN-γ (U/mL)	HBsAg	18 ± 5.3	13.4 ± 5.6	6.8 ± 3.6	0.0011	Ns vs Hy vs Hi
IL-2 (U/mL)	HBsAg	15.9 ± 5.5	8.4 ± 1.6	5.1 ± 1.8	0.0011	Ns vs Hi
TNF-α (pg/mL)	HBsAg	201.5 ± 86.9	64.8 ± 49.0	21.4 ± 4.5	0.0011	Ns vs Hi
IL-12 (pg/mL)	HBsAg	512.8 ± 213.6	117.6 ± 58.2	23.8 ± 7.6	0.0011	Ns vs Hi
IL-10 (pg/mL)	HBsAg	260.8 ± 128.8	60 ± 49.7	47 ± 38.7	0.0011	Ns vs Hi
IL-4 (pg/mL)	HBsAg	83.2 ± 72.3	62.8 ± 44.4	49.2 ± 39.9	-	Not significant

¹Significant; Test of significance was One way ANOVA F-test;

²Multiple comparison by Bonferroni t-test.