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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3328-3337
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3328
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3328
Table 1 Immunopathological characteristics of biliary epithelium in PBC[90]
| Normal | PBC | |
| Expression level of PDC-E2 | + | + + + |
| Adhesion molecules | ||
| - ICAM-1 | + | + + |
| - VCAM-1 | -/+ | + |
| - LFA-1 | -/+ | + |
| - E-selectin | + + | |
| Biliary intra-epithelial lymphocytes | Large bile ducts, few CD4+ | Small bile ducts,increased CD4+CD28- |
| Apoptosis-related molecules | ||
| - Fas (CD95) | - | + |
| - granzyme B | - | -/+ |
| - perforin | - | -/+ |
| - bcl-2 | + + | - |
| BEC phagocytosis of apoptotic BECs | - | + + |
| Cytokines | ||
| - INF-γ | - | + + |
| - IL-2 | - | + + |
| - IL-6 | - | + + |
| - IL-6 receptor | - | -/+ |
| - TNF-α | -/+ | + + |
| - TNF receptor | -/+ | + + |
- Citation: Lleo A, Invernizzi P, Mackay IR, Prince H, Zhong RQ, Gershwin ME. Etiopathogenesis of primary biliary cirrhosis. World J Gastroenterol 2008; 14(21): 3328-3337
- URL: https://www.wjgnet.com/1007-9327/full/v14/i21/3328.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.3328