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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3328-3337
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3328
Table 1 Immunopathological characteristics of biliary epithelium in PBC[90]
NormalPBC
Expression level of PDC-E2++ + +
Adhesion molecules
- ICAM-1++ +
- VCAM-1-/++
- LFA-1-/++
- E-selectin+ +
Biliary intra-epithelial lymphocytesLarge bile ducts, few CD4+Small bile ducts,increased CD4+CD28-
Apoptosis-related molecules
- Fas (CD95)-+
- granzyme B--/+
- perforin--/+
- bcl-2+ +-
BEC phagocytosis of apoptotic BECs-+ +
Cytokines
- INF-γ-+ +
- IL-2-+ +
- IL-6-+ +
- IL-6 receptor--/+
- TNF-α-/++ +
- TNF receptor-/++ +