Clinical features and management of primary biliary cirrhosis

Table 7 Randomized, double-blind, placebo-controlled trials on ursodeoxycholic acid administration to patients with primary biliary cirrhosis

First author	No. of patients	Study design and duration of follow up	UDCA effects on
			Pruritus	Histology	Survival
Poupon[191]	146	2 yr	Improved	Improved	No effect
Heathcote[192]	222	2 yr	No effect	Improved	No effect
Lindor[193]	180	Mean follow up: 2 yr	No effect	No effect	No effect
Combes[194]	151	2 yr	Improved	Improved (early stages)	No effect
Eriksson[195]	116	2 yr + 2 yr as open trial (UDCA)	No effect	No effect	No effect
Pares[196]	192	Mean follow up: 3.4 yr	Improved	Improved	No effect
Papatheodoritis[197]	86	Mean follow up 7.3 yr for UDCA 8.1 yr for controls	Not evaluated	No effect	No effect