Clinical features and management of primary biliary cirrhosis

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Jun 7, 2008 (publication date) through Dec 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2008; 14(21): 3313-3327
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3313

Table 4 Pharmacological characteristics of the opiate antagonists investigated in clinical studies

	Pharmacological characteristics
Naloxone	Very short half life
	Intravenous continuous infusion
	Dose: 0.2-0.4 &mgr;g/kg per minute
Nalmefene	Longer half life
	Oral administration
	2 mg twice/d with a gradual increase until 20 mg twice/d
Naltrexone	Longer half life
	Oral administration
	50 mg/d
	(in two divided doses the first day and subsequently in a unique dose)

Citation: Crosignani A, Battezzati PM, Invernizzi P, Selmi C, Prina E, Podda M. Clinical features and management of primary biliary cirrhosis. World J Gastroenterol 2008; 14(21): 3313-3327
URL: https://www.wjgnet.com/1007-9327/full/v14/i21/3313.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3313