Adenoviral gene therapy in gastric cancer: A review

Table 2 A review of recent methods used in gastric cancer adenoviral gene therapy

Metastasis inhibitors
Gene	Conclusion
NK4	Peritoneal tumors in mice treated early with adenoviral mediated NK4 were significantly reduced.
	In another study Ad.CMV.NK4 resulted in efficient production and secretion of NK4 and significantly inhibited proliferation, migration and invasion of gastric cancer cells[45].
Flt-1	When administered intra peritoneally it markedly reduced the number of metastatic nodules larger than 1 mm in diameter on the peritoneal surface[46].
Caspase 8	In a study it was determined that Caspase 8 can augment anoikis in MKN-45 cells and suppress its peritoneal dissemination in nude mice with xenograft gastric cancer transplants and consequently increase survival, Caspase 8 has also proved to be useful in limiting metastasis in other carcinomas originating from epithelial tissues[37].