Endoscopic ultrasound: It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review

Table 4 Pooled diagnostic accuracy estimates of EUS alone and EUS-FNA for different time periods with 95% CI

Time period	No. of studies	Pooled sensitivity	Pooled specificity	Pooled LR+1	Pooled LR-2	Pooled DOR3
EUS without FNA
1988 to 1994	17	88.0% (85.4-90.2)	85.2% (83.4-86.9)	3.6 (2.4-5.4)	0.2 (0.1-0.3)	27.5 (14.5-52.4)
1995 to 1999	17	82.6% (78.8-85.9)	84.4% (81.6-86.9)	3.0 (2.0-4.5)	0.3 (0.2-0.4)	14.8 (7.5-29.3)
2000 to 2005	10	81.6% (77.8-85.1)	82.4% (78.2-86.1)	3.4 (2.2-5.3)	0.3 (0.2-0.4)	14.9 (6.7-33.1)
EUS-FNA
1988 to 1994	4	71.8% (63.9-78.9)	96.8% (94.9-98.1)	15.5 (2.4-101.2)	0.3 (0.1-0.6)	61.8 (10.5-63.8)
1995 to 1999	10	88.9% (83.5-93.0)	94.7% (90.7-97.3)	8.1 (2.8-23.3)	0.1 (0.1-0.2)	57.0 (20.7-57.1)
2000 to 2005	18	91.7% (89.3-93.7)	96.8% (94.9-98.2)	12.5 (5.2-29.8)	0.1 (0.1-0.2)	17.7 (5.0-62.8)

¹LR+: Positive likelihood ratio; ²LR-: Negative likelihood ratio; ³DOR: Diagnostic odds ratio.