Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal

Figure 1 Overview of CCKAR-immunoreactive ICC seen on cross section of guinea pig gallbladder. A: Low-magnification montage showing C-kit positive cells (arrow) distributed over a band of gallbladder muscle adjacent to the mucosa; B: Low-power montage showing CCKAR-immunoreactive cells distribute mainly in the muscular layers of guinea pig gallbladder; C: Compound micrographs from (A) and (B). Some, but not all C-kit immunoreactive (green) ICC colocalize CCKAR (red), meanwhile, not all CCKAR-immunoreactive cells are ICC; D: Phase-contrast micrographs of the same gallbladders wall at the same magnification.