Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice

Figure 4 Hepatic I/R-induced depletion of reduced form of glutathione and enhanced lipid peroxidation, and effects of apocynin and allopurinol. A: Effect of apocynin or allopurinol on liver GSH levels with the hepatic I/R procedure. Liver GSH content was determined spectrophotometrically and expressed as nanomoles per milligram of protein of the tissue; B: Effects of apocynin or allopurinol on liver MDA levels with I/R procedure. Liver MDA content was determined spectrophotometrically and expressed as nanomoles per milligram of tissue protein (mean ± SEM). ^bP < 0.01 vs Sham controls; ^cP < 0.05, ^dP < 0.01 vs the hepatic I/R procedure plus N.S. at 6 h time point (n = 6 in each group).