Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice

Figure 1 Attenuation of I/R-induced liver injury by apocynin and allopurinol in mice. A-D: Representative micrographs of liver histology (× 100). A: Normal liver; B: I/R-induced liver injury 6 h after starting reperfusion; C and D: Attenuation of liver injury with apocynin (APO) (C) or Allo (allopurinol) (D); E: Serum ALT levels in mice receiving apocynin or allopurinol and subsequently the hepatic I/R procedure. Serum ALT levels were determined 6 h and 24 h after starting reperfusion (n = 6 each group), and expressed as mean ± SEM. ^aP < 0.01 vs I/R procedure plus normal saline (N.S.) at 6 h or 24 h.