Effect of oophorectomy and exogenous estrogen replacement on liver injury in experimental obstructive jaundice

Table 4 Comparison of groups by categories n (%)

Categories	Group 1	Group 2	Group 3	χ2/P
Necrosis
No change	5 (35.7)	12 (85.7)	7 (50)	χ2 = 17.20
Slight	7 (50)	0 (0)	1 (7.1)	P < 0.050
Moderate	2 (14.3)	2 (14.3)	6 (42.9)
Regenerative activity
Slight	6 (42.9)	13 (92.9)	6 (42.9)	χ2 = 10.22
Moderate	5 (35.7)	1 (7.1)	6 (42.9)	P < 0.050
Severe	3 (21.4)	0 (0)	2 (14.2)
Ductular proliferation
Slight	0 (0)	6 (42.9)	1 (7.1)	χ2 = 12.43
Moderate	5 (35.7)	5 (35.7)	4 (28.6)	P < 0.050
Severe	9 (64.3)	3 (21.4)	9 (64.3)
Fibroblastic activity
Slight	1 (7.1)	9 (64.3)	1 (7.1)	χ2 = 31.06
Moderate	9 (64.3)	4 (28.6)	11 (78.6)	P < 0.001
Severe	4 (28.6)	1 (7.1)	2 (14.3)
Kupffer cell abnormalities
Absence	6 (42.9)	12 (85.7)	7 (50)	χ2 = 6.13
Presence	8 (57.1)	2 (14.3)	7 (50)	P < 0.050
Sinusoidal congestion
Absence	13 (92.9)	9 (64.3)	14 (100)	χ2 = 8.17
Presence	1 (7.1)	5 (35.7)	0 (0)	P < 0.050
Portal central venous phlebitis
Absence	3 (21.4)	6 (42.9)	0 (0)	χ2 = 7.64
Presence	11 (78.6)	8 (57.1)	14 (100)	P < 0.050
IFN-γ (pg/mL)	349.46 ± 125.15	764.61 ± 191.95	450.21 ± 98.25	P < 0.001
IL-6 (pg/mL)	839.84 ± 245.05	466.5 ± 106.86	710.02 ± 167.75	P < 0.001