Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model

Figure 1 Histology and enzy-mology evaluation of rat livers treated with D-galactosamine/ lipopolysaccharide (D-GalN/LPS). A: Histological examination of the liver at indicated times after GalN/LPS treatment (hematoxylin-eosin staining, bar = 100 &mgr;m). Arrow heads indicate congested central veins. The arrow in the control group A1 indicates cord-like arrangement of hepatocytes with clear nucleoli. The arrows in the 1 h group A2 indicate infiltrated inflammatory cells. The arrow in the 3 h group A3 indicates swollen hepatocytes. The arrow in the 6 h group A4 indicates disarranged hepatocytes. The arrow in the 12 h group A5 indicates massive necrosis and broken cytolemma; B: Time course of serum ALT and AST in rats received intraperitoneal injection of D-GalN/LPS. Data are represented as mean ± SD, n = 6, ^aP < 0.05 and ^bP < 0.01 vs control group.