Cost-effectiveness analysis of chemotherapy for advanced gastric cancer in China

doi:10.3748/wjg.14.2715

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May 7, 2008 (publication date) through Jul 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. May 7, 2008; 14(17): 2715-2722
Published online May 7, 2008. doi: 10.3748/wjg.14.2715

Table 5 Sensitivity analyses by excluding the studies with a potential heterogeneity

Regimens	Excluding studies contaminated with stage II diseases			Excluding studies from poorly developing areas of China			Excluding studies published before the last 5 years			Excluding the studies weighted more than 25% of overall sample
	Cost	Eff	ICER	Cost	Eff	ICER	Cost	Eff	ICER	Cost	Eff	ICER
Sensitivity analyses of DMC/MST ratio (RMB/mo)
5FU+ADM/EPI+MMC (FAM)	1749.10¹	12.1	Baseline	1822.06	11.9	DT	-	-	-	2257.82¹	10.3	Baseline
5FU+VP-16+CF (ELF)	1775.88	13.0	29.76	1744.78¹	13.0	Baseline	-	-	-	2543.12	11.7	203.79
5FU+CF+DDP+MMC (LFP/M)	3056.08	9.0	DT	3056.08	9.0	DT	-	-	-	-	-	-
5FU+CF+ADM+MTX (FAMTX)	1756.95	6.1	DT	-	-	-	1756.95¹	6.1	Baseline	-	-	-
5FU+EPI+DDP (ECF)	2276.43	8.7	DT	-	-	-	2276.43	8.7	199.8	-	-	-
5FU+DDP+PTX (TCF)	-	-	-	-	-	-	-	-	-	-	-	-
5FU+CF+DXL+DDP (DCF)	-	-	-	-	-	-	-	-	-	-	-	-
5FU+CF+L-OHP (FOLFOX)	-	-	-	-	-	-	-	-	-	-	-	-
UFT+MMC (UFTM)	2441.29	8.5	DT	2441.29	8.5	DT	-	-	-	-	-	-
UFT+DDP+VP-16 (FEP)	1999.97	10.0	DT	1999.97	10.0	DT	-	-	-	-	-	-
DDP+VP-16+ADM/EPI (EAP)	2929.13	9.0	DT	2594.35	8.7	DT	-	-	-	2790.23	8.5	DT
Sensitivity analyses of DMC/CR+PRratio (RMB/%)
5FU+ADM/EPI+MMC (FAM)	1749.10¹	36.0	Baseline	1822.06	36.8	DT	-	-	-	2257.82¹	40.8	Baseline
5FU+VP-16+CF (ELF)	1775.88	57.1	1.27	1744.78 1	56.7	Baseline	-	-	-	2543.12	53.3	22.82
5FU+CF+DDP+MMC (LFP/M)	3056.08	44.0	DT	3056.08	44.0	DT	-	-	-	-	-	-
5FU+CF+ADM+MTX (FAMTX)	1756.95	21.0	DT	-	-	-	1756.95¹	21.0	Baseline	-	-	-
5FU+EPI+DDP (ECF)	2276.43	44.4	DT	4158.00	40.0	DT	2276.43	44.4	22.2	4158.00	40	DT
5FU+DDP+PTX (TCF)	2667.01	50.0	DT	2667.01	50.0	DT	2667.01	50.0	69.75	2667.01	50	DT
5FU+CF+DXL+DDP (DCF)	9979.00	56.3	DT	9979.00	56.3	DT	9979.00	56.3	1160.63	9979.00	56.3	2478.63
5FU+CF+L-OHP (FOLFOX)	3244.31	50.0	DT	3244.31	50.0	DT	3244.31	50.0	DT	3244.31	50	DT
UFT+MMC (UFTM)	2441.29	32.7	DT	2441.29	32.7	DT	-	-	-	-	-	-
UFT+DDP+VP-16 (FEP)	1999.97	47.1	DT	1999.97	47.1	DT	-	-	-	-	-	-
DDP+VP-16+ADM/EPI (EAP)	2929.13	50.0	DT	2594.35	51.9	DT	-	-	-	2790.23	52.5	DT

¹The regimen with the lowest direct medical cost in a single cycle was selected as the common baseline for other regimens to refer to. Eff: Effectiveness; ICER: Incremental cost/effectiveness ratio; CR: Complete response; PR: Partial response; MST: Median survival time; DMC: Per capita direct medical cost of single cycle; DT: Dominated by just the less costly one; 5FU: 5-fluorouracil; ADM: Adriamycin; EPI: Epirubicin; MMC: Mitomycin; DDP: Cisplatin; VP-16: Etoposide; CF: Calcium Leucovorin; UFT: Uracil-tegafur; MTX: Methotrexate; PTX: Paclitaxel; DXL: Docetaxel; L-OHP: Oxaliplatin.

Citation: Chen XZ, Jiang K, Hu JK, Zhang B, Gou HF, Yang K, Chen ZX, Chen JP. Cost-effectiveness analysis of chemotherapy for advanced gastric cancer in China. World J Gastroenterol 2008; 14(17): 2715-2722
URL: https://www.wjgnet.com/1007-9327/full/v14/i17/2715.htm
DOI: https://dx.doi.org/10.3748/wjg.14.2715