Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole

Figure 1 Median intragastric pH during a 6 h post administration period for all subjects (n = 10). The solid line (•) shows the hourly median intragastric pH after administration of 10 mg lafutidine, and the broken line (▪) that after administration of 30 mg LPZ. The median intragastric pH values during the post administration period were significantly higher with lafutidine than with LPZ 2, 3, 4, 5, and 6 h after drug administration. Arrow: drug administration. The statistical significance of differences between the drug groups in intragastric pH among was assessed with the Wilcoxon signed-rank test. ^aP < 0.05 vs LPZ pH.