Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro

Figure 3 A: Effect of AMD3100 on chemotactic migration of CRC cells. The chemotaxis assay indicated that AMD3100 significantly inhibited the CXCL12-mediated migration of SW480 cells at final concentrations of 100 and 1000 ng/mL. The blue-stained cells are those that migrated through the polycarbonate membrane to the lower surface of the membrane (a-c); B: CXCL12 inhibited migration of SW480 cells in a dose-dependent manner. Bars indicate mean ± SD of triplicate experiments. ^aP < 0.05, ^bP < 0.01.