Analysis of risk factors for the interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy

Table 1 Univariate and multivariate analysis of clinicopathologic factors potentially associated with the interval time of hepatic metastases after radical gastrectomy

		Cases of hepatic metastases after surgery
Factor	n	< 6 mo	6-12 mo	12-36 mo	> 36 mo	Univariate P value	Multivariate P value	Odds ratio
Age
≤ 50 yr	13	0	5	7	1	0.634	0.334	0.800
51- 69 yr	55	6	16	22	11	-	-	-
≥ 70 yr	19	3	5	9	2	-	-	-
Gender
Male	77	9	24	31	13	0.309	0.149	1.949
Female	10	0	2	7	1	-	-	-
Gastric carcinoma
Size
≤ 5 cm	39	2	5	21	11	0.001	0.019	1.989
> 5 cm	48	7	21	17	3	-	-	-
Location
Proximal	25	2	10	9	4	0.512	0.966	1.007
Middle	17	1	6	8	2	-	-	-
Distal	43	5	9	21	8	-	-	-
Diffuse	2	1	1	0	0	-	-	-
Histologic differentiation
Poorly undifferentiated	42	6	14	17	5	0.454	0.091	0.629
Well, moderately	45	3	12	21	9	-	-	-
Vascular invasion
Absent	70	6	19	32	13	0.296	0.134	1.928
Present	17	3	7	6	1	-	-	-
Neural invasion
Absent	74	7	20	33	14	0.232	0.383	1.502
Present	13	2	6	5	0	-	-	-
Depth of invasion1
T1	4	0	1	2	1	0.085	0.400	0.845
T2	26	1	5	14	6	-	-	-
T3	48	5	20	18	5	-	-	-
T4	9	3	0	4	2	-	-	-
Lymph node metastases1
N1	31	0	3	19	9	< 0.001	0.001	1.892
N2	37	3	17	13	4	-	-	-
N3	19	6	6	6	1	-	-	-
No. 12 lymph node group metastases
Absent	75	5	21	35	14	0.011	0.880	0.915
Present	12	4	5	3	0	-	-	-
No. 8 lymph node group metastases
Absent	72	5	20	33	14	0.034	0.647	0.792
Present	15	4	6	5	0	-	-	-
Lauren classification
Intestinal	36	4	8	15	9	0.037	0.331	1.171
Diffuse	29	5	13	10	1	-	-	-
Mixed	22	0	5	13	4	-	-	-
Surgical procedure
Esophago-proximal	23	2	1	17	3	0.056	0.481	1.098
Proximal subtotal	8	1	4	2	1	-	-	-
Distal subtotal	45	4	18	14	9	-	-	-
Total	11	2	3	5	1	-	-	-
Ascites
Absent	57	8	17	22	10	0.338	0.608	0.866
Present	30	1	9	16	4	-	-	-
Soft tissue invasion
Absent	47	6	18	17	6	0.170	0.136	0.559
Present	40	3	8	21	8	-	-	-

¹According to pTNM classification of UICC; Esophago-proximal, resection of the distal esophagus and proximal stomach; total, resection of the whole stomach.