Effects of &alpha;-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro

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Apr 21, 2008 (publication date) through Nov 14, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2008; 14(15): 2358-2363
Published online Apr 21, 2008. doi: 10.3748/wjg.14.2358

Table 1 α-adrenoceptor antagonists-induced apoptosis in human pancreatic cancer cells (mean ± SD)

Treatment	TUNEL-positive cells (apoptotic index) (%)
	PC-2	PC-2	PC-3	PC-3
	100&mgr;mol/L	200&mgr;mol/L	100&mgr;mol/L	200&mgr;mol/L
Yohimbine	20.91 ± 2.43^a	39.41 ± 3.21^a	15.47 ± 2.19^a	21.22 ± 2.57^a
Urapidil	1.57 ± 0.94	2.47 ± 1.03	1.98 ± 0.69	2.33 ± 0.92
Control	2.56 ± 0.78		2.14 ± 0.62

^aP < 0.05 vs control.

Citation: Shen SG, Zhang D, Hu HT, Li JH, Wang Z, Ma QY. Effects of α-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro. World J Gastroenterol 2008; 14(15): 2358-2363
URL: https://www.wjgnet.com/1007-9327/full/v14/i15/2358.htm
DOI: https://dx.doi.org/10.3748/wjg.14.2358