A red wine polyphenolic extract reduces the activation phenotype of cultured human liver myofibroblasts

Figure 1 RWPE decreases myofibroblasts proliferation. Myofibroblasts were grown for either three (A) or seven days (B) in the presence of the indicated concentrations of RWPE. Results are the mean ± SD of 4 independent experiments conducted in quadruplicate. The effect of RWPE was highly significant using ANOVA (P < 0.0001). In control experiments, myofibroblasts were exposed to RWPE for 24 h and the DNA content of the cell layer was measured (C). Results are expressed as the percentage of the values in treated cells as compared to cells treated with the solvent alone and are the mean ± SD of 3 independent experiments conducted in quadruplicate. There were no significant differences between conditions.