Troglitazone, a peroxisome proliferator-activated receptor γ ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells

Figure 5 Immunocytochemistry showed that caspase-3 was activated. The shrunken cells were positively stained for activated caspase-3. No positive cell was detectable in the control group ( A: original magnification, × 200). Whereas large numbers of positive cells labeled for activated caspase-3 were observed in HepG2 cells treated with 30 &mgr;mol/L troglitazone for 24 h ( B: original magnification, × 400).