Necrotizing enterocolitis: A multifactorial disease with no cure

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Apr 14, 2008 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2008; 14(14): 2142-2161
Published online Apr 14, 2008. doi: 10.3748/wjg.14.2142

Table 3 Eicosanoid synthesis and actions

Eicosanoid	Cell/tissue origin	Target cell/tissue	Receptor	Action
PGE2	Most cells	Many cells	EP1-EP4	Fever, pain
PGI2	Endothelium	Platelet VSMC	IP	Declumping, vasodilation
PGF2	Uterus	Uterine SMC	FP	Contraction
PGD2	Mast cells	Lung Th2 cells	DP1/DP2	Asthma, chemotaxis
TXA2	Platelets	Platelet VSMC	TPα/TPβ	Aggregation, vasoconstriction
LTB4	Macrophage monocytes	Neutrophils	BLT1/BLT2	Promotes chemotaxis
LTC4/LTD4/LTE4	Macrophage monocytes	Lung SMC	BLT3/BLT4	Bronchoconstriction
LXA4	Leukocytes	Neutrophil	LXA4 R	Inhibits chemotaxis
LXB4	Leukocytes	NK cells	?	Inhibits cytotoxicity

Citation: Schnabl KL, Aerde JEV, Thomson AB, Clandinin MT. Necrotizing enterocolitis: A multifactorial disease with no cure. World J Gastroenterol 2008; 14(14): 2142-2161
URL: https://www.wjgnet.com/1007-9327/full/v14/i14/2142.htm
DOI: https://dx.doi.org/10.3748/wjg.14.2142