Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis

Figure 3 In the control group, the expression of CBP mRNA was at a very low level, the A (optical densit) value of it was nearly 0. After CCl₄ injection, the expression of CBP mRNA in the liver of fibrotic rats was significantly enhanced ( A: ISH, × 200). However, in the livers of the Oxymatrine-treated rats, the expression of CBP was also increased compared to the control group ( B: ISH, × 200), but it was significantly reduced compared to the model group. The A value of CBP mRNA in model group and treated group were 0.235 ± 0.025 and 0.065 ± 0.049, respectively (P < 0.05).