Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis

Figure 1 Subcutaneous injection of CCl₄ caused severe hepatic injury such as significant hepatic cell necrosis and excessive collagen deposition. With Masson staining, the collagen fiber was shown blue and hepatic cells were red. ( A: Masson, × 200). Oxymarine treated livers showed less hepatic cell necrosis and less collagen deposition ( B: Masson, × 200).