Immune-mediated anti-neoplastic effect of intratumoral RSV envelope glycoprotein expression is related to apoptotic death of tumor cells but not to the size of syncytia

Figure 2 Intratumoral expression of RSV-F or RSV-F/G induces an anti-neoplastic effect. In a bilateral subcutaneous syngeneic MC38 or Colon26 colon cancer model, the indicated adenovirus vectors were inoculated on d 0 and d 2 into the tumor on the right flank. No viral vectors were inoculated into the tumor on the left flank. A: The volume of the tumor on the right flank was measured at d 28 and presented as box-and-whisker plots, showing minimum, 25th percentile, median, 75th percentile, and maximum tumor volume; B: The volume of the tumor on the left flank, which did not receive direct viral vector injections, was measured at d 28 and the volume reduction relative to Ad.Null-treated control animals is presented as bar graphs (mean ± SD).