KIT exon 11 codon 557/558 deletion/insertion mutations define a subset of gastrointestinal stromal tumors with malignant potential

Table 2 Clinicopathological and molecular characteristics of GIST patients

Case No.	Sex	Age	Site	Size (cm)	Mitoses (/50 HPF)	Differentiation	CD117	Diagnosis	KIT mutations	PDGFRA mutations
1	F	72	LI	9	6	SP	N	Malignant potential	wt	wt
2	M	65	SI	2.8	10	M1	P	Malignant potential	p.A502-Y503insA	wt
3	M	79	S	16	9	EP	P	Malignant potential	p.K558>NP	wt
4	F	60	SI	17	3	EP	P	Malignant potential	p.K558>NP	wt
5	F	59	SI	5	2	SP	P	Low malignant potential	p.W557-K558del	wt
6	M	72	SI	7.8	2	SP	P	Malignant potential	p.W557-K558del	wt
7	M	82	S	5.5	5	SP	P	Very low malignant potential	p.D579del	wt
8	M	52	SI	4	3	SP	P	Low malignant potential	p.V559A	wt
9	F	63	S	8	7	SP	P	Malignant potential	p.V559A	wt
10	F	70	SI	6	1	M1	P	Malignant potential	p.W557-K558del	wt
11	F	60	S	9	4	M1	P	Very low malignant potential	wt	p.D842V
12	M	61	S	13	2	M2	P	Low-moderate malignant potential	wt	p.I 843-D846del
13	M	64	S	9	3	SP	P	Very low malignant potential	wt	wt
14	F	70	S	1.5	1	SP	P	Benign	p.P551-Q556del	wt
15	M	66	S	10	20	SP	P	Malignant potential	wt	wt
16	M	60	SI	12	4	SP	P	Malignant potential	p.Y503-F504insAY	wt
17	F	62	SI	3.5	1	SP	P	Low malignant potential	pV560D	wt
18	M	56	SI	4	1	SP	P	Low malignant potential	p.K550-E554del	wt
19	F	67	S	19	22	M1	P	Malignant potential	p.K550-K558del	wt
20	F	46	S	19	10	EP	P	Malignant potential	wt	wt
21	F	61	S	3.5	3	SP	P	Very low malignant potential	wt	wt
22	M	57	LI	8	5	SP	P	Malignant potential	pV560D	wt
23	M	58	S	0.7	0	SP	P	Benign	p.V559-G565del	wt
24	M	60	S	7.5	3	M2	P	Very low malignant potential	wt	wt
25	M	67	S	8	1	M2	P	Very low malignant potential	wt	wt
26	M	72	S	5.5	1	SP	P	Very low malignant potential	p.Y503-F504insAY	wt
27	F	70	LI	17	9	SP	P	Malignant potential	p.W557-K558del	wt
28	M	61	LI	2.6	6	SP	P	Malignant potential	p.P551-K558del	wt
29	F	53	S	5	0	SP	N	Very low malignant potential	wt	wt
30	F	57	LI	2.5	0	SP	P	Low malignant potential	wt	wt

S: Stomach; SI: Small intestine; LI: Large intestine; SP: Spindle cell; EP: Epithelioid; M1: Mixed type 1; M2: Mixed type 2; P: Positive; N: Negative.