Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index

Table 4 COX-2 genotypes and risk for CRC in association with smoking status, alcohol duration and BMI

	-765GG		-765GC+CC
	Controls/cases	OR (95% CI)	Controls/cases	OR (95% CI)
Smoking status
Never	126/68	1	21/7	1
Smoker	43/51	2.682 (1.336-5.385)b	9/11	7.963 (0.615-103.051)
Alcohol duration (yr)
Never	143/89	1	25/14	1
1-15	13/12	0.750 (0.303-1.855)	3/2	0.713 (0.044-11.599)
> 15	13/18	0.810 (0.259-2.531)	2/2	0.199 (0.005-7.669)
Body mass index (BMI)
18.5-22.9	86/31	1	15/4	1
23-24.9	32/46	3.909 (2.081-7.344)	6/8	5.128 (0.867-30.320)
> 25	51/42	2.031 (1.107-3.726)d	9/6	6.281 (0.864-45.631)

^bP = 0.006 vs non-smoker group,

^dP < 0.001 vs normal BMI group (All estimates are multivariate adjusted for age, gender, smoking status, alcohol consumption and body mass index).