Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

doi:10.3748/wjg.14.1749

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Mar 21, 2008; 14(11): 1749-1758
Published online Mar 21, 2008. doi: 10.3748/wjg.14.1749

Table 2 Etiology-dependent frequency of dysregulated transcripts within functionally defined subsets

	HCV patients (n = 10)			Alcoholic patients (n = 12)
			Tumor/cirrhosis¹			Tumor/cirrhosis
Subset: Regulation of cell cycle (GO 0000074)²
CCT4³	Hs.421509⁴	1.38 (7)^a
ZAK	Hs.444451	1.44 (8)
CUL1	Hs.146806	1.69 (7)
MAPRE1	Hs.472437	1.78 (10)	χ²
CLK1	Hs.433732	1.80 (7)	P < 0.05
CKS2	Hs.83758	1.92 (8)
NME1	Hs.463456	1.97 (9)
CDC37	Hs.160958	2.05 (6)				-
TSC1	Hs.370854	2.60 (6)^a
Subset: Transcription factor (GO 0003700)
IRF6	Hs.355827	0.55 (10)^b		RUNX1	Hs.149261	0.67 (12)^b
FOSL2	Hs.220971	0.58 (10)^a		NR3C1	Hs.122926	1.68 (12)^b
ETS2	Hs.592158	0.79 (10)^b
IRF2	Hs.374097	0.83 (9)
DSCR1	Hs.282326	1.53 (10)
NR4A3	Hs.279522	1.63 (7)^a
ZNF397	Hs.84307	1.72 (10)	χ²
HMGA1	Hs.518805	1.75 (9)	P < 0.05
SPIB	Hs.437905	1.77 (10)
NME1	Hs.463456	1.97 (6)^a
ATF3	Hs.460	2.22 (6)
MSRB2	Hs.461420	2.32 (6)
DSIPI	Hs.420569	2.51 (7)
IRF3	Hs.75254	2.70 (7)
Subset: Acute phase response (GO 0006953)
CRP⁵	Hs.76452	0.46 (10)^a		AHSG	Hs.324746	0.84 (12)
APCS⁵	Hs.507080	0.84 (10)^a	χ²	ORM1	Hs.567311	1.24 (12)
			P < 0.05	SAA2⁵	Hs.1955	1.84 (11)^a
				SAA1⁵	Hs.632144	1.90 (11)^a
				CRP⁵	Hs.76452	2.17 (12)

¹Average ratio of mRNA levels in tumor and cirrhotic tissue in patients with a detectable expression of this mRNA. The number of such patients is indicated in brackets and a significant difference between tumors and paired cirrhotic tissues per etiology is indicated (^aP < 0.05;

^bP < 0.01; Wilcoxon’s non parametric, paired test).

²Subset of mRNAs coding for proteins with a shared function as identified by Gene Ontology (GO) number.

³Dysregulated mRNAs, as defined by an abnormal tumor/cirrhosis ratio found in at least 3 patients of at least one etiology group (total 475 mRNAs; HCV, 301; alcoholism, 174). The dysregulated mRNAs with an ontology-defined function (HCV, 183; alcoholism, 100) were a subset of the 475 mRNAs.

⁴Hs. number as a unique mRNA identifier.

⁵Only 5 of the 23 mRNAs listed in Figure 2B appear herein because the other mRNAs in Figure 2B belonged to functional classes in which the number of mRNAs was not different in alcoholic vs HCV patients.

Citation: Derambure C, Coulouarn C, Caillot F, Daveau R, Hiron M, Scotte M, François A, Duclos C, Goria O, Gueudin M, Cavard C, Terris B, Daveau M, Salier JP. Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma. World J Gastroenterol 2008; 14(11): 1749-1758
URL: https://www.wjgnet.com/1007-9327/full/v14/i11/1749.htm
DOI: https://dx.doi.org/10.3748/wjg.14.1749