Angiopoietin-1 targeted RNA interference suppresses angiogenesis and tumor growth of esophageal cancer

Figure 3 Effect of Ang-1si on esophageal cancer growth in vivo. Grossly, the Eca109/Ang-1si tumors were significantly smaller than those in both control groups; Under microscopy, massive necrotic tissue was found in Eca109/Ang-1si tumors, while Eca109 and Eca109/si tumors showed fine necrosis; the Eca109/Ang-1si tumors were avascular with lower MVD, while Eca109 and Eca109/si tumors appeared very vascularized with higher MVD; Eca109/Ang-1si tumors underwent massive apoptosis with more TUNEL-positive cells compared with Eca109 and Eca109/si tumors, which showed a finely granular cytoplasm with evenly dispersed chromatin and lower TUNEL-positive cells.