Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

Figure 4 Combination index (CI) vs fraction affected (f_a) plots obtained from the median-effect analysis program (CalcuSyn, Biosoft, Cambri-dge, UK). (A) and (B) A549; (C) and (D) HepG2. Curves with solid lines are computer simulated f_a-CI plots, based on parameters (m and D_m values) for cisplatin and herbal extract combinations. Circles are actual combination data points. CI < 1, = 1 and > 1 indicates synergism, additive effect and antagonism, respectively.