Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India

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Mar 14, 2008 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

H Pylori

World J Gastroenterol. Mar 14, 2008; 14(10): 1498-1503
Published online Mar 14, 2008. doi: 10.3748/wjg.14.1498

Table 3 H pylori infection and COX-2 polymorphism as risk for gastric adenocarcinoma

H pylori status	COX-2 genotype	Gastric adenocarcinoma (n = 62)	Non-ulcer dyspepsia (Controls, n = 241)	OR (95% CI)	P-value
HP-	GG	8	79	Referent
HP-	C carriers	19	29	7.06 (2.61-19.09)	< 0.001
HP+	GG	6	92	0.83 (0.26-2.59)	0.747
HP+	C carriers	29	41	7.83 (3.09-19.85)	< 0.001

HP-: H pylori negative; HP+: H pylori positive.

Citation: Saxena A, Prasad KN, Ghoshal UC, Bhagat MR, Krishnani N, Husain N. Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. World J Gastroenterol 2008; 14(10): 1498-1503
URL: https://www.wjgnet.com/1007-9327/full/v14/i10/1498.htm
DOI: https://dx.doi.org/10.3748/wjg.14.1498