Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India

doi:10.3748/wjg.14.1498

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2008; 14(10): 1498-1503
Published online Mar 14, 2008. doi: 10.3748/wjg.14.1498

Table 2 Allelic distribution of COX-2 polymorphism in gastric adenocarcinoma, peptic ulcer disease and non-ulcer dyspepsia

COX-2 genotype	Gastric adenocarcinoma	Peptic ulcer disease	Non-ulcer dyspepsia
COX-2 genotype	(n = 62)	(n = 45)	(n = 241)
GG (%)	14 (22.6)	31 (68.9)	171 (71)
GC (%)	29 (46.8)	12 (26.7)	62 (25.7)
CC (%)	19 (30.6)	2 (4.4)	8 (3.3)
C carrier (%)¹	48 (77.4)	14 (31.1)	70 (29)

¹Gastric adenocarcinoma vs non-ulcer dyspepsia: P < 0.001; Gastric adeno-carcinoma vs peptic ulcer disease: P < 0.001; Peptic ulcer disease vs non-ulcer dyspepsia: P = 0.74.

Citation: Saxena A, Prasad KN, Ghoshal UC, Bhagat MR, Krishnani N, Husain N. Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. World J Gastroenterol 2008; 14(10): 1498-1503
URL: https://www.wjgnet.com/1007-9327/full/v14/i10/1498.htm
DOI: https://dx.doi.org/10.3748/wjg.14.1498