Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score

Table 3 Survival between two groups in HCC patients by multivariate analysis

	Disease-free survival		Overall survival
	HR (95% CI)	P-value	HR (95% CI)	P-value
Child-Pugh classification
B vs A	2.05 (1.25-3.35)	0.004	2.46 (1.38-4.41)	0.002
Tumor size
≥ 5 vs < 5 cm	1.26 (0.83-1.92)	0.282	1.30 (0.75-2.25)	0.350
Macroscopic findings1
Confluent type vs	1.10 (0.75-1.61)	0.626	1.58 (0.92-2.72)	0.098
Simple nodular type
Number of tumor
Multiple vs Solitary	1.23 (0.82-1.85)	0.306	1.73 (1.03-2.91)	0.037
Vascular involvement
Yes vs No	1.24 (0.68-2.27)	0.481	1.76 (0.93-3.31)	0.080
Alpha-feto protein level
≥ 400 vs < 400 ng/mL	1.41 (0.93-2.11)	0.103	1.36 (0.81-2.28)	0.250
Treatment modality
Ablation vs Hepatectomy	0.75 (0.46-1.22)	0.239	0.64 (0.39-1.34)	0.334

¹Macroscopic findings defined by the Classification of Primary Liver Cancer[17].