Topic Highlight
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2007; 13(9): 1399-1407
Published online Mar 7, 2007. doi: 10.3748/wjg.v13.i9.1399
Figure 6
Figure 6 Schematic of the biomechanical model developed in Edwards and Chapman[44]. Proliferation in the epithelium generates stress within the layer through cellular attachment to the underlying basal lamina. For certain choices of the model parameters, the stress that is generated causes the layer to buckle, inducing a displacement y and initiating crypt budding and fission.