KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro

doi:10.3748/wjg.v13.i9.1445

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Mar 7, 2007 (publication date) through Oct 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2007; 13(9): 1445-1448
Published online Mar 7, 2007. doi: 10.3748/wjg.v13.i9.1445

Table 2 Effect of 10 μmol/L KN-93 and KN-92 on cell proliferation in human hepatic stellate cells (LX-2) after treatment for various periods of time (n = 3, mean ± SD)

	Cell proliferation (% of control)
Time of treatment	KN-93	KN-92
Control	100.00 ± 2.86	100.00 ± 3.32
4 h	99.56 ± 3.53	97.12 ± 2.97
8 h	78.27 ± 2.92^b	96.95 ± 2.56
16 h	52.26 ± 2.90^b	98.34 ± 3.18
24 h	30.54 ± 2.82^b	96.53 ± 2.67
48 h	11.48 ± 3.16^b	97.12 ± 3.09

^bP < 0.01 vs control group.

Citation: An P, Zhu JY, Yang Y, Lv P, Tian YH, Chen MK, Luo HS. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol 2007; 13(9): 1445-1448
URL: https://www.wjgnet.com/1007-9327/full/v13/i9/1445.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i9.1445