Comethylation of p16 and MGMT genes in colorectal carcinoma: Correlation with clinicopathological features and prognostic value

Figure 3 Overall survival among the patients with CRC according to the methylation status of p16 and MGMT genes (A), and mutational status of K-ras gene (B). Overall survival is longer in the group of the patients with simultaneous methylation of p16 and MGMT gene than in group with no simultaneous or any methylation (P = 0.072, Log-rank test). Overall survival is significantly lower in the group of patients with mutated K-ras than in group with unchanged, wild type K-ras gene (P < 0.001, Log-rank test). Survival curves were constructed by Kaplan-Meier method.