Comethylation of p16 and MGMT genes in colorectal carcinoma: Correlation with clinicopathological features and prognostic value

doi:10.3748/wjg.v13.i8.1187

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Feb 28, 2007 (publication date) through Mar 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Feb 28, 2007; 13(8): 1187-1194
Published online Feb 28, 2007. doi: 10.3748/wjg.v13.i8.1187

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Figure 1 Analysis of p16 (A) and MGMT (B) gene methylation by MSP. The presence of a visible PCR product in lanes U indicates the presence of unmethylated genes of p16 (151 bp) and MGMT (93 bp); the presence of product in lanes M indicates the presence of methylated genes of p16 (150 bp) and MGMT (81 bp). The samples of colorectal carcinoma 1, 2 and 4 show p16 promoter hypermethylation, while 6, 8 and 9 show MGMT promoter hypermethylation. NL-normal lymphocytes as a positive control for unmethylated alleles; Raji-commercial cell line as a positive control for methylated alleles; St-molecular weight marker (50 bp).

Citation: Krtolica K, Krajnovic M, Usaj-Knezevic S, Babic D, Jovanovic D, Dimitrijevic B. Comethylation of p16 and MGMT genes in colorectal carcinoma: Correlation with clinicopathological features and prognostic value. World J Gastroenterol 2007; 13(8): 1187-1194
URL: https://www.wjgnet.com/1007-9327/full/v13/i8/1187.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i8.1187