Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy

Table 4 Complexity evolution in HCV quasispecies from SVR and NR patients in ISDR, PKRbd and V3 domains

Patient	Time of treatmentdomains	D0ISDR-PKRbd-V3	M3ISDR-PKRbd-V3	M6ISDR-PKRbd-V3
SVR1	n = 15	3–4–3	-	-
SVR2	n = 13	3–4–2	-	-
SVR3	n = 8	3–5–3	-	-
SVR4	n = 16–13	3–7–3	3–4–3	-
SVR5	n = 15–17	8–8–1	4–7–1	-
SVR6	n = 17–6	8–9–3	1–2–3	-
SVR7	n = 15–17	6–6–7	6–7–7	-
NR1	n = 17–9–4	6–8–7	3–4–4	1–3–2
NR2	n = 17–12–10	7–8–2	5–8–3	3–4–6
NR3	n = 14–11–12	6–7–4	5–7–3	4–5–2

Amino acids sequences were compared to HCV-J; n: number of PCR products analyzed.