Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma

Figure 3 Expression of CYP2C8, CYP2E1, CYP3A4, and CYP3A5 in macroscopically normal tissue of SCC patients and controls. A: Representative photomicrograph of RT-PCR products determined in normal tissue of patients with untreated esophageal SCC (S) and controls (C). All measurements were carried out in dupilcate. Lanes 1, 6: histone 3.3, lanes 2, 7: CYP2C, lanes 3, 8: CYP2E1, lanes 4, 9: CYP3A4, lanes 5, 10: CYP3A5; B: Quantitative analysis of CYP2C, CYP2E1, CYP3A4, and CYP3A5 mRNA expression in normal esophageal tissue of SCC patients and controls. Results are normalized to histone 3.3 expression. Data are means ± SE. ^aP < 0.05 vs normal tissue.