p53 gene in treatment of hepatic carcinoma: Status quo

Table 2 Approaches for restoring tumor suppression function of p53 in the treatment of HCC

Strategies	Therapeutic effects
Chemotherapy or radiotherapy	Inducing p53-dependent apoptosis in tumor cells with wt-p53
Supplying exogenous wt-p53 by gene delivery	Suppressing growth of both mutant and wild-type p53-containing tumor cells
Overexpression of ARF	Blocking p53 degradation pathways to induce p53 triggered tumor cell death
Interruption of MDM2-p53 interaction	Preventing MDM2-mediated p53 ubiquitinationand degradation to restore transactivation
Molecules stabilizing the active conformation of the protein	Rescuing mt-p53 to restore p53 function