p53 gene in treatment of hepatic carcinoma: Status quo

Table 1 Abnormal p53 status detected in HCC with probable mechanisms

Endogenous status of p53 or its pathways	Probable mechanisms
Mutation of p53 gene	Point mutation, allele deletion, insertion, etc.
Loss of or decrease in wt-p53 expression	Enhanced p53 degradation, complex formation
Hyperactivities of negative regulators of p53	No p53 mutation, over- expressed negative regulators of p53 attenuate its function
Increased diversity of p53 aberration	Progression of HCC
Presence of serum anti-p53 antibodies	Over-expression of wt-p53, presence of mt-p53, or both