NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

Table 1 Various biomarkers of colitis

	Ulcer index	Colon length	Colon Wt.(Total) (gm)	Distal Colon wt. (last 8 cm) (gm)	MPO Units/gmof tissue	LPO nmol/L per100 mg	ALP IU/100 mg
Control	0.00 ± 0.00	19.88 ± 0.41	1.46 ± 0.05	0.52 ± 0.02	2.98 ± 0.42	145.75 ± 13.78	26.63 ± 3.45
Positive control	4.50 ± 0.25b	15.75 ± 0.39b	2.18 ± 0.13b	1.33 ± 0.10b	5.63 ± 0.46b	296.23 ± 23.98b	252.13 ± 33.69d
Sulfasalazine (100 mg/kg)	2.75 ± 0.39f	18.13 ± 0.37h	1.76 ± 0.05j	0.84 ± 0.05h	3.60 ± 0.29j	211.54 ± 32.23j	136.38 ± 17.69j
NCB-02 (25mg/kg)	3.75 ± 0.23	15.13 ± 0.37	1.98 ± 0.14	1.22 ± 0.13	4.27 ± 0.45	259.38 ± 28.71	232.38 ± 33.79
NCB-02 (50mg/kg)	3.00 ± 0.18j	16.50 ± 0.31	1.88 ± 0.15	1.09 ± 0.09	3.90 ± 0.32	205.69 ± 22.09j	186.88 ± 24.86
NCB-02 (100mg/kg)	2.63 ± 0.25f	18.13 ± 0.45h	1.69 ± 0.07j	0.90 ± 0.06j	3.73 ± 0.30j	174.84 ± 13.06h	153.13 ± 20.23j

^bP < 0.001,

^dP < 0.01 vs control;

^fP < 0.001,

^hP < 0.01,

^jP < 0.05 vs positive control.