Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human

doi:10.3748/wjg.v13.i7.1042

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Feb 21, 2007 (publication date) through Jan 20, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2007; 13(7): 1042-1052
Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1042

Table 2 Summary of in situ grading of sequential autoradi-ographic and immunohistochemical staining signals

Radioactiveiron/protein	Iron status	Basal	5 min	15 min	30 min	2h
⁵⁹Fe	ID	-	SUR+	IE+++	IE+++	-
	OL	-	SUR+++	IE±	IE±	-
Tf	ID	IV±	IV++	IE+++		IE+
				IV++		IV++
	OL	IV±	IE±	IE±
			IV±	IV±
TfR	ID	SUR±	SUR++	IE++	IE+	SUR±
	OL	SUR±	SUR++	SUR+	-	-
Fe	ID	IE±				IE±
		IV±	-	-
	OL	IE±	-		IE±	IE±
						IV+++

Tf: transfferin; TfR: Transferrin receptor; Fe: Ferritin; ID: Iron deficient; OL: Iron overload; IE: Intra epithelial; IV: Intra vascular; SUR: Surface; Grading +: minimal staining; ++: good; +++: intense; –: nil.

Citation: Kolachala VL, Sesikeran B, Nair KM. Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human. World J Gastroenterol 2007; 13(7): 1042-1052
URL: https://www.wjgnet.com/1007-9327/full/v13/i7/1042.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i7.1042