Rab23 is a potential biological target for treating hepatocellular carcinoma

Table 1 Expression of Rab23 in HCC (in-situ hybridization and immunohistochemistry)

	In-situ hybridization			Iimmunohistochemistry
	Pos	Neg	P	Pos	Neg	P
Normal	0	5		0	5
Paracarcinoma	0	18		0	18
HCC	38	33		48	19
Tumor
Differentiation
Well	4	3		6	1
Mod and poor	34	30	0.3028	42	18	0.2681
Metastasis
Yes	9	5		10	4
No	29	28	0.2663	38	15	0.2591
Tumor size
Small	3	11		4	13
Large	35	22	0.0072	35	15	0.001
Age
≥ 50 yr	14	10		15	9
< 50 yr	24	23	0.5613	33	10	0.2149
Sex
Male	29	26		44	15
Female	9	7	0.8036	4	4	0.1156
HBsAg
Pos	34	31		46	17
Neg	4	2	0.2721	2	2	0.2517
AFP
≥ 20 μg/L	26	24		35	12
< 20 μg/L	12	9	0.6917	13	7	0.4314

Statistical analysis was performed by Fisher’s exact test or Binomial proportions analysis. A P value < 0.05 was considered statistically significant. Pos: positive signal; Neg: Negative signal; Well: Well-differentiated tumors; Mod-poor: Moderately to poorly differentiated tumors.